Polymorphisms of Complement Component I and C1R Subcomponent of Cl in Nine Aboriginal Taiwanese Populations

Document Type

Brief Communication

Authors

Kazuo Umetsu, Yamagata University School of Medicine
Isao Yuasa, Tottori University School of Medicine
Tsuneo Suzuki, Yamagata University School of Medicine
Sun Cheih-Shan, National Taitung Hospital, Republic of China
Pan I-Hung, National Taiwan University Medical School
Takafumi Ishida, University of Tokyo
Saitou Naruya, National Institute of Genetics, Japan
Satoshi Horai, National Institute of Genetics, Japan

Abstract

Complement component I (IF) and C1R subcomponent of Cl (C1R) types were determined by isoelectric focusing and subsequent immunoblotting techniques for 658 individuals from nine aboriginal Taiwanese populations. The frequency of the IF*A allele ranges from 0.075 (Bunun) to 0.430 (Saisiat), and a new variant allele IF*B2 was found to have polymorphic frequency in the Atayal. The frequency of the C1R*1 allele ranges from 0.410 (Yami) to 0.650 (Atayal), and the frequency of the C1R*2 allele ranges from 0.265 (Atayal) to 0.586 (Saisiat). The C1R*5 allele was found in five populations (Atayal, Bunun, Ami, Puyuma, Yami), and the C1R*9 allele was found in two populations (Tsou, Puyuma). The results indicate a remarkable degree of genetic variability among these populations. The variability may reflect long-term genetic and geographic isolation of each population.

Recommended Citation

Umetsu, K., Yuasa, I., Suzuki, T., Cheih-Shan, S., I-Hung, P., Ishida, T., ... Horai, S. (1994). Polymorphisms of complement component I and C1R subcomponent of Cl in nine aboriginal Taiwanese populations. Human Biology, 66(2), 339-348.