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Restriction fragment length polymorphisms at the renin and factor 13B loci located at chromosome 1q32-1q42 were studied in 14 ethnic groups in the west Pacific region. The allele frequencies were combined with previously described β-globin and albumin-vitamin D binding protein haplotype frequencies and used to assess genetic affinities among eight major ethnic-geographic groups in this region. These population groups divide into two clusters with Australian Aborigines, Ilasnd Melanesians, and Highland Melanesians forming one cluster and east Asians, Southeast Asians, Micronesians and Polynesians forming the other. The resulsts indicated that Micronesians and Polynesians are derived from populations in Southeast Asia and that they originated independently of the Melanesian populations.