Genetic Epidemiology of Non-Insulin-Dependent Diabetes Mellitus in North India: Preliminary Analyses of Some Genetic Markers in Punjabis

Document Type

Brief Communication

Authors

P S. Gill, Trinity University
S M.S Chahal, Punjabi University
J Blangero, Southwest Foundation for Biomedical Research
R S. Corruccini, Southern Illinois University
I J.S Bansal, Department of Human Biology, Punjabi University
S S. Kaul, Department of Anthropology, Panjab University
V Bhalla, Department of Anthropology, Panjab University

Abstract

Studies on monozygotic (MZ) twins and admixed populations show that the predisposition to non-insulin-dependent diabetes meliitus has a large genetic component. We have examined the distribution of some genetic polymorphisms (ABO, GLO, ESD, AK, ACPA, and GPI) in control and diabetic Punjabis from north India. The distribution of various genetic markers indicate that the differences between the control and diabetic samples are statistically not significant. Moreover, a contingency chi-square analysis over all loci suggests nonsignificant genetic differentiation (p = 0.50) between the Punjabi samples. Authors also include I.J.S. Bansal (Punjabi University) S.S. Kaul (Panjab University) and V. Bhalla (Panjab University)

Recommended Citation

Gill, P S.; Chahal, S M.S; Blangero, J; Corruccini, R S.; Bansal, I J.S; Kaul, S S.; and Bhalla, V (1991) "Genetic Epidemiology of Non-Insulin-Dependent Diabetes Mellitus in North India: Preliminary Analyses of Some Genetic Markers in Punjabis," Human Biology: Vol. 63: Iss. 4, Article 11.
Available at: https://digitalcommons.wayne.edu/humbiol/vol63/iss4/11