Developmental Expression of Tyrosyl Kinase Activity in Human Serum

Document Type

Article

Authors

Ming-Fong Lin, Louisiana State University Medical Center, Oregon Health Sciences University
Joan E. Baily-Wilson, Louisiana State University Medical Center
Robert C. Elston, Louisiana State University Medical Center
Gail M. Clinton, Louisiana State University Medical Center, Oregon Health Sciences University

Abstract

Tyrosine protein kinases, in addition to their roles as viral transforming proteins and growth factor receptors, have been suggested to have specialized functions in tissue specific processes and in differentiation. High levels of soluble tyrosine kinases have been found in human serum and plasma. To determine if the level of tyrosine kinase activity is developmen- tally expressed in human serum, we assayed sera from 214 individuals of different ages from newborns to 90 years. We found that serum tyrosine kinase levels are high in newborns and the levels closely parallel skeletal growth until late adolescence. The serum tyrosine kinase levels increase again corresponding to the second and third decades and decline by the fourth decade of life. These studies show that tyrosine kinase levels are developmentally expressed in human serum and delineate the stages in post­natal development when changes in expression occur.

Recommended Citation

Lin, Ming-Fong; Baily-Wilson, Joan E.; Elston, Robert C.; and Clinton, Gail M. (1987) "Developmental Expression of Tyrosyl Kinase Activity in Human Serum," Human Biology: Vol. 59: Iss. 3, Article 14.
Available at: https://digitalcommons.wayne.edu/humbiol/vol59/iss3/14