MNSs Genetic Polymorphism and Intrauterine Selection Through Habitual Abortion

Document Type

Article

Authors

E Bottini, 2nd University of Rome School of Medicine and Lincei National Academy, Rome
E Bonci, Lincei National Academy, Rome
F Gloria-Bottini, Lincei National Academy and 1st University of Rome School of Medicine
M Nicotra, 1st University of Rome School of Medicine
E Carapella, 1st University of Rome School of Medicine
I Coghi, 1st University of Rome School of Medicine
N Lucarini, University of Camerino School of Science, Italy
A Martini, University of Camerino School of Science, Italy
D Paris, 2nd University of Rome School of Medicine
M Bonci, 2nd University of Rome School of Medicine
G Finocchi, 2nd University of Rome School of Medicine

Abstract

Distribution of MNSs genotypes and possible relation with gestational duration of aborted fetuses were studied in 88 couples with habitual abortion. An excess of couples S females X s males with respect to expected values assuming random mating was observed. The duration of gestation of aborted fetuses showed a negative linear relation with maternal doses of s and a positive linear relation with paternal dose of s. Mean gestational duration revealed a significant heterogeneity in relation to MN and Ss types of mating. A striking increase of mean gestational duration of aborted fetuses was observed in couples mother S X father s. Sialoglycopro- teins similar to glycophorins controlled by MNSs system may be present at trophoblastic level and their genetic variability may contribute to modula­tion of maternal fetal immunological relationship. On the basis of recent studies suggesting that MNSs system may be an important determinant of graft-versus host disease and that HLA restricted proliferative responses occurs in vitro in association with M and N antigens, the possibility of maternal-fetal incompatibility in this system should be also considered.

Recommended Citation

Bottini, E; Bonci, E; Gloria-Bottini, F; Nicotra, M; Carapella, E; Coghi, I; Lucarini, N; Martini, A; Paris, D; Bonci, M; and Finocchi, G (1987) "MNSs Genetic Polymorphism and Intrauterine Selection Through Habitual Abortion," Human Biology: Vol. 59: Iss. 1, Article 10.
Available at: https://digitalcommons.wayne.edu/humbiol/vol59/iss1/10