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The hypothesis that response to hepatitis B virus (HBV) infection in parents is related to the sex ratio (M/F x 100) of offspring was tested in families from two communities in East Greenland. The results (based on tests on mothers only) support the previous findings from Greece, France, Papua New Guinea and the Philippines. Mothers with hepatitis B surface antigen (HBsAg) (“carriers”) had a higher sex ratio than non'Carriers, and mothers with anti-HBs had a lower sex ratio than the carriers and mothers with no evidence of infection.