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This paper demonstrates that serum levels of the adrenal androgen, dehydroepiandrosterone sulfate (DHEAS), are significantly associated (p < .03) with levels of fatness in males during early, middle and late adolescence. Relatively high levels of DHEAS are also associated with advanced skeletal age (SA), independent of the association of SA and levels of testosterone. This evidence supports our hypothesis that increased fatness prepubertally may potentiate increased levels of adrenal androgens and precipitate earlier sexual maturation. This interaction between body fat and adrenal androgen levels after adrenarche may account for the recent secular trend toward earlier sexual maturation.