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β-thalassemia major has been known to interfere with the normal development of various body systems, retarding maturation and skeletal growth. The development of the dentition was expected to be affected as well. A sample of 43 β-thalassemia major patients of both sexes, ranging in age between 9 months and 20 years, was assessed for skeletal and dental age. Development of the dentition was retarded. Chronological, skeletal and dental age showed no obvious correlation with each other. While dental age retardation increased linearily with age, peaking at 27%, skeletal age retardation, which was much more severe, was most pronounced in the youngest age group, reaching a maximum of 73%.