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Two sets of measurements of Japanese infants with Down’s syndrome bom in Tokyo and its outskirts were analysed to look for a secular trend. The earlier set was obtained in 1964-1966, and the later one in 1974-1976. These data comprised mean values of stature, weight, chest girth, head girth, upper limb length, and lower limb length. The secular increase, which is seen in normal infants, was not found in Down’s syndrome infants. It is suggested that chromosome-21 trisomy may have reduced the adaptability of Down’s syndrome infants to environmental changes.