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Single endocrine experiments lend themselves to misinterpretations of a direct relationship between the experiment and subsequent morphological changes. Many endocrine ablations and manipulations produce a depression of body growth and morphological changes similar to those following nutritional deprivation. When the data are corrected for body size by means of covariance analysis it becomes possible to differentiate between biomechanical changes that are merely a function of changing body size and those that are of specific endocrine etiology.