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Document Type

Article

Abstract

The prepubertal child has an active hypothalamic-pituitary-gonadal axis. Small but measurable amounts of sex steriods and gonadotropic hormones exist before the time of sexual maturation and interact in a negative feed­back fashion. Puberty in man involves a change in the level of activity of the negative feedback system and the appearance of a positive feedback relationship between gonad and neural centers.

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