Local Genotypic Disequilibrium in a Generalized Island Model

Document Type

Article

Authors

Henry Harpending, University of New Mexico, Albuquerque, New Mexico
Peter Workman, University of Massachusetts, Amhers, Massachusetts
John Grove, University of Hawaii, Honolulu, Hawaii

Abstract

In a subdivided population which is mating at random except for a proportion, E, of marriages which are endogamous in excess of random endogamy, and in which the Wahlund coefficient of inbreeding, which measures gene frequency variance among subdivisions, is Rst, the expected value of Wright’s Fjs, which measures deviation from local Hardy-Weinberg equilibrium, is approximately Rst(E — 1) and is thus negative. This effect and others which have been described combine to make the Fjs parameter nearly uninterpretable.

Recommended Citation

Harpending, Henry; Workman, Peter; and Grove, John (1973) "Local Genotypic Disequilibrium in a Generalized Island Model," Human Biology: Vol. 45: Iss. 3, Article 5.
Available at: https://digitalcommons.wayne.edu/humbiol/vol45/iss3/5