Access Type

Open Access Thesis

Date of Award

January 2017

Degree Type

Thesis

Degree Name

M.S.

Department

Pharmaceutical Sciences

First Advisor

Arun K. Iyer

Abstract

Redox-responsive cerium oxide nanoparticles (CNPs) can play a versatile role in cancer therapy due to their ability to induce oxidative stress under proper pH conditions. Hyaluronic acid micelles with a high affinity to CD44 receptor which achieved more cytotoxicity towards cancer cells. The polymer-coated CNPs and HA-SMA-TPGS-CDF nanomicelles were developed for cancer therapy. The results showed that the toxicity of CNPs in tumor cells was mediated by the pro-oxidant property of CNPs under relative low pH conditions (pH~6.5) of the tumor microenvironment whereas CNPs play a (cytoprotective) anti-oxidant role, scavenging reactive oxygen species and reducing oxidative stress under normal pH conditions or pH~7.4). HA-SMA-TPGS-CDF nanomicelles held promising effective and potentially deliver approach to for intracellular delivery of 3,4-difluorobenzylidene diferuloylmethane due to higher accumulation and more cytotoxicity in cancers. Next, we will fabricate a combined nanodelivery structure having cerium oxide nanoparticles and HA-SMA-TPGS copolymer for the treatment of cancers, warranting further investigations.

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