Access Type

Open Access Thesis

Date of Award

January 2014

Degree Type

Thesis

Degree Name

M.S.

Department

Nutrition and Food Science

First Advisor

Ahmad R. Heydari

Abstract

Many studies have investigated the effects of rapamycin on aging and cancer. However, the effects of long-term rapamycin supplementation on a cancer model have not been performed. This is the first study that investigates the effects of long-term supplementation of rapamycin in a cancer model. ACF analysis of colon tissues in mice showed no significant difference between controls and those supplemented with rapamycin. Factors such as energy balance, cellular environment, PI3K/Akt/mTOR pathway, and more have been assessed in this study. The duration of rapamycin supplementation seems to play an important role in the protection against cancer. Ultimately, this study suggests that the long-term supplementation of rapamycin in C57BL/6 mice provides a protective mechanism and influences many cellular processes involved in cancer. Interestingly, a correlation between this study and folate deficiency's influence and protection of β-pol+/- haploinsufficient mice has also been noticed.

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