The concept of Neighbor Balanced Block (NBB) designs is defined for the experimental situation where the treatments are combinations of levels of two factors and only one of the factors exhibits a neighbor effect. Methods of constructing complete NBB designs for two factors in a plot that is strongly neighbor balanced for one factor are obtained. These designs are variance balanced for estimating the direct effects of contrasts pertaining to combinations of levels of both the factors. An incomplete NBB design for two factors is also presented and is found to be partially variance balanced with three associate classes.