A linear B-spline function was modified to model dose-specific response variation in developmental toxicity studies. In this new model, response variation is assumed to differ across dose groups. The model was applied to a developmental toxicity study and proved to be significant over the previous model of singular response variation.
Li, Chin-Shang and Hunt, Daniel L.
"A Linear B-Spline Threshold Dose-Response Model with Dose-Specific Response Variation Applied to Developmental Toxicity Studies,"
Journal of Modern Applied Statistical Methods:
2, Article 22.
Available at: http://digitalcommons.wayne.edu/jmasm/vol8/iss2/22