A Linear B-Spline Threshold Dose-Response Model with Dose-Specific Response Variation Applied to Developmental Toxicity Studies

Authors

Chin-Shang Li, University of California, DavisFollow
Daniel L. Hunt, Radiation Therapy Oncology Group, Philadelphia, PAFollow

Abstract

A linear B-spline function was modified to model dose-specific response variation in developmental toxicity studies. In this new model, response variation is assumed to differ across dose groups. The model was applied to a developmental toxicity study and proved to be significant over the previous model of singular response variation.

DOI

10.22237/jmasm/1257034860