"Tests for 2X2 Tables in Clinical Trials " by Vic Hasselblad and Yulia Lokhnygina
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Abstract

Five standard tests are compared: chi-squared, Fisher's exact, Yates’ correction, Fisher’s exact mid-p, and Barnard’s. Yates’ is always inferior to Fisher’s exact. Fisher’s exact is so conservative that one should look for alternatives. For certain sample sizes, Fisher’s mid-p or Barnard’s test maintain the nominal alpha and have superior power.

DOI

10.22237/jmasm/1193890140

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