Linkage Disequilibria and Haplotype Structure of Four SNPs of the Interleukin 1 Gene Cluster in Seven Asian Indian Populations

Document Type

Article

Authors

Srilakshmi M. Raj, Oxford University
Ranajit Chakraborty, University of Cincinnati College of Medicine
Ning Wang, Cincinnati Children's Hospital Medical Center
Diddahally R. Govindaraju, Oxford UniversityFollow

Abstract

Variation at four single nucleotide polymorphism (SNP) sites of the interleukin 1 (IL1) gene cluster was investigated among 280 unrelated individuals, representing 7 caste groups from the state of Karnataka, India, and one European American community of Boston, Massachusetts. Allele and haplotype frequencies, strength of linkage disequilibrium, and signatures of recombination varied considerably among populations. Variable community sizes and traditions of consanguinity may account for the observed variation.

Recommended Citation

Raj, Srilakshmi M.; Chakraborty, Ranajit; Wang, Ning; and Govindaraju, Diddahally R. (2006) "Linkage Disequilibria and Haplotype Structure of Four SNPs of the Interleukin 1 Gene Cluster in Seven Asian Indian Populations," Human Biology: Vol. 78: Iss. 1, Article 9.
Available at: https://digitalcommons.wayne.edu/humbiol/vol78/iss1/9