Several polymorphisms in the insulin receptor substrate-1 (IRS1) gene have been reported in the last years. The most common IRS1 variant, a Gly VArg substitution at codon 972 (Arg972 IRS1), is more prev- alent among subjects who have features of insulin resistance syndrome asso- ciated, or not, with type 2 diabetes in European populations. To determine whether the absence of IRS1 polymorphism is a more general characteristic of Paleo-Indian-derived populations, we examined the Arg972 IRS1 poly- morphism in Parakana ̃ Indians and found a lack of this polymorphism in the Parakana ̃ population.
Bezerra, Rosâgela M.N.; Chadid, Thiago T.; Altemani, Claúdia M.; Sales, Teresa S.I.; Menezes, Taimundo; Soares, Manoel C.P.; Saad, Sara T.O.; and Saad, Mario J.A.
"Lack of Arg972 Polymorphism in the IRS1 Gene in Parakana ̃ Brazilian Indians,"
1, Article 9.
Available at: http://digitalcommons.wayne.edu/humbiol/vol76/iss1/9