Short Tandem Repeat Polymorphism of the D2S1242 Locus in a Japanese Population

Document Type

Article

Authors

Jian Tie, Department of Legal Medicine, Nihon University School of Medicine, Tokyo, 173-8610 Japan.
Yuka Suzuki, Department of Legal Medicine, Nihon University School of Medicine, Tokyo, 173-8610 Japan.
Shojiro Tsukamoto, Department of Legal Medicine, Nihon University School of Medicine, Tokyo, 173-8610 Japan.
Shigemi Oshida, Department of Legal Medicine, Nihon University School of Medicine, Tokyo, 173-8610 Japan.

Abstract

Allele frequencies and sequence characteristics of the D2S1242 short tandem repeat (STR) locus were studied in a Japanese population sample. A total of 10 D2S1242 alleles and 34 genotypes were identified in 273 unrelated Japanese individuals. The five most common alleles detected had frequencies of over 10%. No deviations from Hardy-Weinberg equilibrium were found when the expected allele values were compared with the observed values. Sequence analysis of each allele showed a tetranucleotide polymorphism. Alleles 9 to 14 had different sequence structures than alleles 15 to 19. Allele 18 had a different sequence in the Japanese sample compared to an Austrian sample. The power of discrimination was 0.95. The present results demonstrate that the D2S1242 STR locus is a useful genetic marker in the Japanese population.

Recommended Citation

Tie, Jian; Suzuki, Yuka; Tsukamoto, Shojiro; and Oshida, Shigemi (2002) "Short Tandem Repeat Polymorphism of the D2S1242 Locus in a Japanese Population," Human Biology: Vol. 74: Iss. 4, Article 8.
Available at: https://digitalcommons.wayne.edu/humbiol/vol74/iss4/8