To assess evidence for a gene with large effect on systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI), we conducted segregation analyses on 261 nuclear families collected from a rural Caucasian community in Michigan. The families were ascertained through a hypertensive proband. Each phenotype was adjusted for significant covariate effects (e.g., gender and age). We used class D regressive models to conduct the segregation analyses. Our analysis results support the segregation of a major gene for BMI, but not for SBP or DBP. A recessive locus effect provided the best explanation for BMI where ∼43% of the variance of BMI was due to this gene.
Nath, Swapan K.; Chakravarti, Aravinda; Chen, Chien-Hsiun; Cooper, Richard; Weder, Alan; and Schork, Nicholas J.
"Segregation Analysis of Blood Pressure and Body Mass Index in
a Rural US Community,"
1, Article 2.
Available at: http://digitalcommons.wayne.edu/humbiol/vol74/iss1/2