Genetic Variations of Cholesterol Ester Transfer Protein Gene in Koreans

Document Type

Article

Authors

Seung Ho Hong, Department of Medicine, University of Maryland, Baltimore.
Young-Ree Kim, Department of Clinical Pathology, Medical College, Korea University, Seoul, Korea.
Junghan Song, Department of Clinical Pathology, Seoul National University Hospital and College of Medicine, Seoul, Korea.
Jin Q. Kim, Department of Clinical Pathology, Seoul National University Hospital and College of Medicine, Seoul, Korea.

Abstract

An absence of cholesterol ester transfer protein (CETP, protein; CETP, gene) results in an increase of the apolipoprotein AI levels and a decrease in the low density lipoprotein (LDL) levels. Thus, the CETP polymorphism is important in the assessment of risk of atherosclerosis. This study was conducted to elucidate the genotype distributions of the CETP polymorphism and association with plasma lipid levels in Koreans. The genotypes of the TaqI A and B polymorphic loci were associated with plasma triglyceride levels in the control and coronary artery disease (CAD) groups. There was linkage disequilibrium between TaqI A and B loci in the control group (χ2 = 5.58, p < 0.05). Association studies of the CETP polymorphism have been carried out mainly with Caucasian populations; however, the results have not been consistent among different populations. A possible explanation for this diversity among populations may be differences in genetic backgrounds, which may be more important than environmental factors. We discuss the reasons for the incompatibility of the CETP polymorphism among populations.

Recommended Citation

Hong, Seung Ho; Kim, Young-Ree; Song, Junghan; and Kim, Jin Q. (2001) "Genetic Variations of Cholesterol Ester Transfer Protein Gene in Koreans," Human Biology: Vol. 73: Iss. 6, Article 3.
Available at: https://digitalcommons.wayne.edu/humbiol/vol73/iss6/3