Activin is a multifunctional hormone playing a major role in the regulation of reproduction and growth and development. We performed a genomewide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in the activin-to-estrogen ratio in baboons. A microsatellite polymorphism, D19S714, which maps to human chromosome 19p13.2, showed marginal evidence of linkage with a lod (log10 of the odds in favor of genetic linkage) score of 1.95 (0.014). This region contains several potential candidate genes including PKA (protein kinase, cAMP-dependent, catalytic α) and the gene pair JUN-B and JUN-D. This is the first evidence of a quantitative trait locus with a significant effect on the activin-to-estrogen ratio.
Martin, Lisa J.; Blangero, John; Rogers, Jeffrey; Mahaney, Michael C.; Hixson, James E.; Carey, K. Dee; and Comuzzie, Anthony G.
"A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio
in Pedigreed Baboons Maps to a Region Homologous to Human
6, Article 1.
Available at: http://digitalcommons.wayne.edu/humbiol/vol73/iss6/1