Document Type
Article
Abstract
Apolipoprotein B (apoB, protein; APOB, gene) is the main protein component of low-density lipoprotein (LDL) and plays an important role in blood lipid metabolism. Previously, we have reported four APOB coding regions, 5¢ signal peptide, and 3¢ repeat sequence polymorphisms in our population. In this report, we further characterize other APOB genetic variations. The results illustrate that the mutation frequencies for Arg3500Gln (1/846 alleles), Arg4019Trp (2/786 alleles), –265 C/T promoter region (0/264 alleles), and intron 2 A/G (0/450 alleles) are very low. Our population showed a frequency of 68.9% for the B4311 Ser allele. The B4311 Asn allele was associated with a higher apoB level than the Ser group (p < 0.05) in normal controls. In the normal controls, a higher B4311 Asn/Asn genotype frequency was found in the group with total cholesterol (TC) > 200 mg/dL and apoB concentration > 85 mg/dL than in the group with a TC < 200 mg/dL and apoB < 85 mg/dL (p = 0.03 for TC comparison).
Recommended Citation
Wu, June Hsieh; Lee, Yauan-The; Hsu, Hsiu-Ching; Hsieh, Ling-Ling; Wen, Ming-Shien; Chern, Ming-Shyan; and Wu, Delon
(2001)
"Further Characterization of Apolipoprotein B Genetic Variations
in Taiwanese,"
Human Biology:
Vol. 73:
Iss.
3, Article 9.
Available at:
https://digitalcommons.wayne.edu/humbiol/vol73/iss3/9
