Allele frequencies for human deoxyribonuclease I (DNase I) phenotypes were determined using blood samples from about 2000 Japanese subjects living in nine prefectures, and compared with one another. DNase I phenotyping was performed principally using isoelectric focusing electrophoresis and activity staining. The DNase I system was shown to have enhanced potential for anthropologic, genetic, and clinical studies of Japanese populations. DNase I phenotypes were analyzed to evaluate the degree of genetic variation at the DNASE1 locus. Our examination of DNase I types revealed a decreasing north-ta-south gradient in the DNASE1 allele.
Takeshita, Haruo; Yasuda, Toshihiro; Nakashima, Yoshimitsu; Mogi, Kouichi; Kishi, Koichiro; Shiono, Hiroshi; Sagisaka, Karou; Yuasa, Isao; Nishimukai, Hiroaki; and Kimura, Hiroshi
"Brief Communications Geographical North-South Decline in DNASE! *2 in Japanese Populations,"
1, Article 9.
Available at: http://digitalcommons.wayne.edu/humbiol/vol73/iss1/9