The SRY-1532 Site of the Human Y Chromosome Is Subject to Recurrent Single Nucleotide Mutations

Document Type

Article

Authors

Gutala Ramana, University of Texas School of Public Health
Lalji Singh, Centre for Cellular and Molecular Biology, Hyderabad, India
Ranajit Chakraborty, University of Texas School of Public Health

Abstract

Haplotype determination based on three Y -linked polymorphic sites, 92R7 (Crr), SRY-1532 (AJG), and YAP (-/+), in 127 males belonging to three caste Hindu populations of South India (Vizag Brahmins, Peruru Brahmins, and Kammas) and 13 males belonging to a lrugrant group (the Siddis) showed the existence of all four haplotypes (CA-, CG-, TG-, and TA-) under the YAP- background. This finding suggests that the reverse mutation (G --+ A) at the SRY -1532 site, described earlier in the literature, is present in South Indian populations as well. The YAP + mutation was seen in only five Siddi individuals. Four of these were of the CG + haplotype structure, but a novel haplotype (CA + ) was found in one male. To explain the Qccunence of the six baplotypes found within these three sites, a haplotype tree is constructed that introduces a new reverse mutation at the SRY -1532 site (G -)0 A), occuning under the CG + background after the migrant Siddi population arrived in India.

Recommended Citation

Ramana, Gutala; Singh, Lalji; and Chakraborty, Ranajit (2001) "The SRY-1532 Site of the Human Y Chromosome Is Subject to Recurrent Single Nucleotide Mutations," Human Biology: Vol. 73: Iss. 1, Article 4.
Available at: https://digitalcommons.wayne.edu/humbiol/vol73/iss1/4