The frequency of the butyrylcholinesterase K mutation was calculated on the basis of data obtained by polymerase chain reaction primer-introduced restriction analysis (PCR-PIRA). The population sample was composed of 177 Brazilians: 95 whites of predominantly European ancestry and 82 admixed individuals (European and African origin). The frequencies—18.4 ± 2.8% for whites and 17.1 ± 2.9% for admixed did not differ from those previously obtained in North America, Scotland, Japan, and Denmark. The occurrence of the K mutation in Europeans, East Asians, and Africans suggests a relatively old origin for this mutation, and the similar frequencies found in these populations may suggest the operation of selective forces.
Souza, R.L.R.; Castro, R.M.V.; Pereira, L.; Freund, A.A.; Culpi, L.; and Chautart-Freire-Maja, E.A.
"Frequencies of the Butyrylcholinesterase K Mutation in Brazilian Populations of European and African Origin,"
5, Article 10.
Available at: http://digitalcommons.wayne.edu/humbiol/vol70/iss5/10