Application of HLA Class II Polymorphism Analysis to the Study of the Population Structure of the Island of Krk, Croatia

Document Type

Article

Authors

Irena Martinović, Institute for Anthropological Research, U1, grada Vukovara
Maja Bakran, Institute for Anthropological Research, U1, grada Vukovara
André Chaventré, Universite de Bordeaux II
Branka Janićijevic, Institute for Anthropological Research, U1, grada Vukovara
Veljko Javanović, Institute for Anthropological Research, U1, grada Vukovara
Nina Smolej-Naranćić, Institute for Anthropological Research, U1, grada Vukovara
Andriija Kaštelan, University of Zagreb
Zorana Grubrić, University of Zagreb
Renata Žunec, University of Zagreb
Derek F. Roberts, University of Newcastle upon Tyne
Pavao Rudan, Institute for Anthropological Research, U1, grada Vukovara

Abstract

The population structure of the northern Adriatic island of Krk, Croatia, was studied using PCR methodology and nonradioactive oligonucleotide hybridization for the analysis of HLA-DRB1, DRB3, DRB4, DRB5, DQA1, and DQB1 polymorphisms. Allele frequencies, genetic kinship (R), and genetic distances (E2) were computed, and correlations between distance (genetic, linguistic, geographic) and kinship (migration) matrices were examined. The results, reflecting past (micro-) evolutionary processes, indicate that ethnohistorical and sociocultural events rather than geographic distances are the primary determinants of today’s population structure of the island.

Recommended Citation

Martinović, Irena; Bakran, Maja; Chaventré, André; Janićijevic, Branka; Javanović, Veljko; Smolej-Naranćić, Nina; Kaštelan, Andriija; Grubrić, Zorana; Žunec, Renata; Roberts, Derek F.; and Rudan, Pavao (1997) "Application of HLA Class II Polymorphism Analysis to the Study of the Population Structure of the Island of Krk, Croatia," Human Biology: Vol. 69: Iss. 6, Article 6.
Available at: https://digitalcommons.wayne.edu/humbiol/vol69/iss6/6