Brief Communications: Rare β-Thalassemia Mutation in a Turkish Patient: FSC-36/37 (-T)

Document Type

Brief Communication

Authors

Ghazi Omar Tadmouri, Boǧaziçi University
Şükrü Tüzmen, Boǧaziçi University
A. Nazli Başak, Boǧaziçi University

Abstract

We describe the rare /7-thalassemia mutation at codons 36/37 (-T) for the first time in Turkey. The propositus is a Turkish patient with /^-thalassemia major who originated in Adana but now resides in Istanbul. Molecular analysis revealed a compound heterozygosity for the common eastern Mediterranean mutation IVS-I-110 (G-A) along with mutation FSC-36/37 (-T). The FSC-36/37 (-T) mutation could have arisen somewhere in the region, including northern Iran and the inaccessible mountainous region of eastern Anatolia. The mutation could have followed two migration routes during the time of Ottoman rule, the first being to Azerbaijan and the second, probably a more recent one, passing through southeastern Anatolia and reaching southern Bulgaria.

Recommended Citation

Tadmouri, Ghazi Omar; Tüzmen, Şükrü; and Başak, A. Nazli (1997) "Brief Communications: Rare β-Thalassemia Mutation in a Turkish Patient: FSC-36/37 (-T)," Human Biology: Vol. 69: Iss. 2, Article 9.
Available at: https://digitalcommons.wayne.edu/humbiol/vol69/iss2/9