Serum levels of alpha-1-antitrypsin were measured by radial immunodiffusion, and phenotypes were determined by electro focusing in acrylamide gel in 160 subjects who were used as controls in a case-control study of hepatocellular carcinoma (HCC). The results were studied in relation to age, sex, diagnostic category, tobacco smoking, consumption of alcoholic beverages, presence of hepatitis B surface antigen (HBsAg), and serum levels of alphafetoprotein (AFP) by modeling the data through multiple regression. There was no relation of serum alpha-1-antitrypsin values with sex, HBsAg, AFP, consumption of alcoholic beverages, and diagnostic category (p > 0.25). By contrast, there were statistically significant dose-dependent positive associations of serum alpha-1-antitrypsin with age and tobacco smoking (p < 0.01 in both instances). The positive association of serum alpha-1-antitrypsin with tobacco smoking and the previously reported excessive elevation of serum alpha-1-antitrypsin in hepatitis B-negative tobacco-related cases of HCC suggest that alpha-1-antitrypsin is intimately related to the pathogenetic process linking tobacco smoking to HCC.
Petridou, E; Chapuis-Celier, C; Roukas, K; Lan, S.-J.; Tzonou, A; and Trichopoulos, D
"Tobacco Smoking and Other Factors in Relation to Serum Alpha-1-Antitrypsin,"
3, Article 6.
Available at: http://digitalcommons.wayne.edu/humbiol/vol65/iss3/6