The effects of ABO blood groups and black admixture on the level of factor VIII:C are studied in healthy adults from Salvador, Bahia, Brazil. A racially mixed sample of 125 males was selected as follows: 25 whites, 25 light mulattoes, 25 medium mulattoes, 25 dark mulattoes, and 25 blacks. Levels of both factor VIII:C and KPTT followed normal distributions. O blood group subjects showed lower factor VIII:C levels (110.20 ± 30.76%) than non-0 blood group members (135.24 ± 31.42%) (* 123 = 4.47; p < 0.0001) and higher KPTT levels (37.69 ± 4.57 s) than non-O blood group subjects (35.25 ± 3.82 s) (*123 = 3.24; p < 0.01). By holding ABO blood type constant, there is a significant racial effect (white) on lowering the factor VIII:C level within both blood group O (*43 = 2.23; p < 0.05) and non-O (*36 = 3.44; p < 0.002). There is no interaction effect of race and blood group (F = 0.19; p > 0.6) on the factor VIII:C levels.
Lima, A. M.V.M.D. and Azevêdo, E. S.
"Factor VIII:C, ABO Blood Groups, and Black Admixture in a Brazilian Sample,"
1, Article 7.
Available at: http://digitalcommons.wayne.edu/humbiol/vol63/iss1/7