Enzyme Polymorphism and Clinical Variability of Diseases: Study of Acid Phosphatase Locus 1 (ACPI) in Obese Subjects

Document Type

Article

Authors

E. Bottini, Chair of Human Development, 2d University of Rome, School of Medicine, Rome, Italy.
N. Lucarini, Department of Genetics, University of Camerino, School of Science, Camerino, Italy
G. Gerlini, Department of Child Health, 1st University of Rome, School of Medicine, Rome, Italy
G. Finocchi, Chair of Human Development, 2d University of Rome, School of Medicine, Rome, Italy.
G. Sciré, Chair of Human Development, 2d University of Rome, School of Medicine, Rome, Italy.
F. Gloria-Bottini, Chair of Human Development, 2d University of Rome, School of Medicine, Rome, Italy.

Abstract

The ACP1*A allele of erythrocyte acid phosphatase (ACPI) has a lower enzymatic activity when compared to other ACPI alleles and is associated with maximal rate of body growth during intrauterine life. In three different samples of obese subjects (total num ber = 218). ACP1*A was associated with extreme body mass deviations. No difference in ACPI allele distribution was observed between obese and nonobese subjects. These data suggest that a genetically determined variability of ACPI influences the degree of obesity, but only when obesity itself has been triggered by some other factors.

Recommended Citation

Bottini, E.; Lucarini, N.; Gerlini, G.; Finocchi, G.; Sciré, G.; and Gloria-Bottini, F. (1990) "Enzyme Polymorphism and Clinical Variability of Diseases: Study of Acid Phosphatase Locus 1 (ACPI) in Obese Subjects," Human Biology: Vol. 62: Iss. 3, Article 6.
Available at: https://digitalcommons.wayne.edu/humbiol/vol62/iss3/6