Bias in the Estimation of Inbreeding Coefficient and Probability of Origin of Qenes with Errors in Genealogy

Document Type

Article

Authors

P. Darlu, I.N.S.E.R.M., Unité de recherche de génétique épidémiologique, Université Paris, Paris
M. H. Cazes, I.N.E.D., Paris

Abstract

The estimations of the inbreeding coefficient and of the probability of origin of genes are usually based upon genealogical information and are therefore sensitive to various errors such as misassignment of paternity or maternity, faults in documents or records, and fields errors. By using different examples of errors in the pedigree, it is demonstrated that the bias in the inbreeding coefficient can be very large, while the probability of origin of genes is less affected. If no accurate estimate of the different errors can be obtained, the comparisons of inbreeding coefficients calculated for different populations or generations are very suspect.

Recommended Citation

Darlu, P. and Cazes, M. H. (1988) "Bias in the Estimation of Inbreeding Coefficient and Probability of Origin of Qenes with Errors in Genealogy," Human Biology: Vol. 60: Iss. 6, Article 7.
Available at: https://digitalcommons.wayne.edu/humbiol/vol60/iss6/7