A critical appraisal and clinical application of: DeVore GR, Owens O, Kase N. Use of intravenous Premarin in the treatment of dysfunctional uterine bleeding--a double-blind randomized control study. Obstet Gynecol. 1982 Mar;59(3):285-91.
This appraisal identifies significant statistical irregularities in the study. A reworking of the study's statistics leads to a conclusion different from that put forth by the authors of this paper: intravenous estrogen therapy is not, in fact, significantly more effective compared to placebo therapy for the cessation of acute abnormal uterine bleeding.
Simmer S. Intravenous estrogen is not proven effective for abnormal uterine bleeding: guidelines are based on flawed evidence. Clin. Res. Pract. 2015;1(1):eP1003. doi: 10.22237/crp/1423243521